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Long-Acting Opioids

Fentanyl transdermal patches

(generic; Duragesic ®)

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A Fentanyl (Duragesic) patch is a long-acting opioid medication in the form of a patch that you stick on your skin. When placed on the skin, fentanyl patches release a steady dose of fentanyl into your system over the course of about 3 days.

How do I use this medicine?

You should change your fentanyl patch on a regular schedule, according to your prescription. When it is time to change your patch, simply remove the old patch and place a new patch on your skin.  See below for specific instructions on how to do this. 

Continue using your fentanyl patch, even if your pain is under control. Long-acting opioids like fentanyl patches work in the background to lower your overall pain level.  If you stop using it suddenly, you can have symptoms of withdrawal including worsening pain, nausea, and diarrhea.

To learn more about long-acting opioids, watch this video:

How do I place and change my patch?

Tap on the link below to learn the steps to place and change your fentanyl patch:

Frequently asked questions:

  • Always follow the instructions on your prescription bottle.
    Never take a higher dose of your opioids, or take them more often than prescribed. Instructions on medicine bottles can be confusing. Short-acting opioids are often prescribed with a range of doses you can take. For example: “Take 1-2 tablets every 3 hours as needed for pain.” This means it’s OK to take up to 2 tablets within a 3-hour time window. You can also choose to take less than this, or not take it at all (if your pain is controlled). Take them with a sip of water, with or without food.
  • Take them when you have pain and need quick relief.
    These take about 30 minutes to start working and 1 ½ hour to get the most relief, so take them early on when you feel your pain creeping up.
  • If you don’t have pain, don’t take them.
    If your pain is manageable and you don’t expect it to get worse, you shouldn’t take this medicine. It should be used “as needed” when you have pain.
  • Take them before your pain gets severe.
    Try to “stay ahead” of your pain by taking your short-acting opioid early on when you notice your pain getting worse. If you wait until your pain is severe, it often takes more medication and a longer time to get your pain under control. Pay attention to your body as you learn about your pain and how you react to opioids. Most people start recognizing their body’s signals about when they need to take their short-acting opioid for breakthrough pain.
  • Choose the dose that matches your pain level.
    Most short-acting opioid prescriptions have a range of doses you can choose to take within a given time-period. A common example is take 1-2 tablets every 3 hours as needed. If your pain is severe, start with the higher dose (for example: 2 tablets). If your pain is less severe, you can start with the lower dose (for example: 1 tablet). If your pain isn’t significantly better after 30 minutes to an hour, you can take the rest of the dose.
  • Take them about 30 minutes before painful activities.
    Some people know they will have pain with certain activities, like walking or taking a long car ride. Think of activities that usually worsen your pain. To help you be more active, you may want to take your short-acting opioid 30 minutes beforehand.
  • If your short-acting opioid is not working well, talk to your care team.
    Every person is different and it can take some time to find the right medicines and right doses for you. Your care team might decide to increase the dose of your opioid or change to a different medication. The important thing is to let them know how you are doing.

What are the side effects?

Some people notice side effects when starting this medicine or increasing the dose. The side effects are similar to most opioids, including:

  • Constipation

  • Sedation (sleepiness)

  • Dizziness

  • Fatigue

  • Nausea

Tap to learn about the different side effects and ways to manage them.

How can I be safe when using this medicine?

  • Always follow the instructions on your prescription bottle.
    Never take a higher dose of your opioids, or take them more often than prescribed. Instructions on medicine bottles can be confusing. Short-acting opioids are often prescribed with a range of doses you can take. For example: “Take 1-2 tablets every 3 hours as needed for pain.” This means it’s OK to take up to 2 tablets within a 3-hour time window. You can also choose to take less than this, or not take it at all (if your pain is controlled). Take them with a sip of water, with or without food.
  • Take them when you have pain and need quick relief.
    These take about 30 minutes to start working and 1 ½ hour to get the most relief, so take them early on when you feel your pain creeping up.
  • If you don’t have pain, don’t take them.
    If your pain is manageable and you don’t expect it to get worse, you shouldn’t take this medicine. It should be used “as needed” when you have pain.
  • Take them before your pain gets severe.
    Try to “stay ahead” of your pain by taking your short-acting opioid early on when you notice your pain getting worse. If you wait until your pain is severe, it often takes more medication and a longer time to get your pain under control. Pay attention to your body as you learn about your pain and how you react to opioids. Most people start recognizing their body’s signals about when they need to take their short-acting opioid for breakthrough pain.
  • Choose the dose that matches your pain level.
    Most short-acting opioid prescriptions have a range of doses you can choose to take within a given time-period. A common example is take 1-2 tablets every 3 hours as needed. If your pain is severe, start with the higher dose (for example: 2 tablets). If your pain is less severe, you can start with the lower dose (for example: 1 tablet). If your pain isn’t significantly better after 30 minutes to an hour, you can take the rest of the dose.
  • Take them about 30 minutes before painful activities.
    Some people know they will have pain with certain activities, like walking or taking a long car ride. Think of activities that usually worsen your pain. To help you be more active, you may want to take your short-acting opioid 30 minutes beforehand.
  • If your short-acting opioid is not working well, talk to your care team.
    Every person is different and it can take some time to find the right medicines and right doses for you. Your care team might decide to increase the dose of your opioid or change to a different medication. The important thing is to let them know how you are doing.

Tap for more information about using opioids safely.

Want to learn more?
Check out these resources:
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